A method for designing high-affinity, specific binders to peptide–MHC complexes may improve the next generation of antigen-specific T cell-based therapeutics.
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References
Du, H. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02466-y (2024).
Du, H. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02505-8 (2024).
D’Angelo, S. P. et al. Lancet 403, 1460–1471 (2024).
Nathan, P. et al. N. Engl. J. Med. 385, 1196–1206 (2021).
Cameron, B. J. et al. Sci. Transl. Med. 5, 197ra103 (2013).
Li, Y. et al. Nat. Biotechnol. 23, 349–354 (2005).
Kieke, M. C. et al. Proc. Natl Acad. Sci. USA 96, 5651–5656 (1999).
Yang, X. et al. Nat. Biotechnol. 41, 932–943 (2023).
Wang, L. et al. Nat. Struct. Mol. Biol. 14, 169–171 (2007).
Huang, P.-S. et al. PLoS One 6, e24109 (2011).
Birnbaum, M. E. et al. Cell 157, 1073–1087 (2014).
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Balivada, P.A., Gaglione, S.A. & Birnbaum, M.E. A synthetic scaffold to target peptide–MHC complexes. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02513-8
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DOI: https://doi.org/10.1038/s41587-024-02513-8
