To enhance the safety and security of the US bioeconomy, a new public–private partnership should be established to facilitate information sharing and threat analysis among industry, government and academia, and to develop and deploy safeguards.
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References
Carlson, R. H., Sbragia, C. L. & Sixt, K. M. Beyond biological defense: biotech in U.S. national security and great power competition. https://www.ida.org/research-and-publications/publications/all/b/be/beyond-biological-defense-biotech-in-us-national-security-and-great-power-competition (IDA, 2021).
Executive order on advancing biotechnology and biomanufacturing innovation for a sustainable, safe, and secure American bioeconomy. https://www.whitehouse.gov/briefing-room/presidential-actions/2022/09/12/executive-order-on-advancing-biotechnology-and-biomanufacturing-innovation-for-a-sustainable-safe-and-secure-american-bioeconomy/ (White House, 2022).
National Academies of Sciences, Engineering and Medicine. Safeguarding the Bioeconomy https://nap.nationalacademies.org/catalog/25525/safeguarding-the-bioeconomy (National Academies Press, 2020).
Attal-Juncqua, A., Getz, J., Morhard, R. & Gronvall, G. K. mSphere https://doi.org/10.1128/msphere.00084-24 (2024).
Carter, S. & DiEuliis, D. Health Secur. 17, 403–406 (2019).
Carter, S. R. & DiEuliis, D. Synthetic biology industry practices and opportunities for biosecurity and potential roles for the U.S. Government. https://wmdcenter.ndu.edu/Portals/97/SynBio-Industry-and-Biosecurity-Nov-201912.pdf (National Defense University, 2019).
Proestou, M., Schulz, N. & Feindt, P. H. Ambio 53, 376–388 (2024).
Halford, C. & Harper, M. ASIAS: Aviation Safety Information Analysis and Sharing. In 2008 IEEE/AIAA 27th Digital Avionics Systems Conference https://doi.org/10.1109/DASC.2008.4702784 (IEEE, 2008).
Rose, S., Alexanian, T., Langenkamp, M., Cozzarini, H. & Diggans, J. Appl. Biosaf. 29, 159–171 (2024).
ISO 35001:2019. Biorisk management for laboratories and other related organizations. https://www.iso.org/standard/71293.html (ISO, 2019).
CHIPS Act of 2022. https://www.congress.gov/117/plaws/publ167/PLAW-117publ167.pdf (Government Publishing Office, 2022).
Administration for Strategic Preparedness and Response. Screening framework guidance for providers and users of synthetic nucleic acids. https://aspr.hhs.gov/legal/synna/Documents/SynNA-Guidance-2023.pdf (Department of Health and Human Services, 2023).
National Science and Technology Council. Framework for nucleic acid synthesis screening. https://www.whitehouse.gov/wp-content/uploads/2024/04/Nucleic-Acid_Synthesis_Screening_Framework.pdf (Office of Science and Technology Policy, 2024).
United States Government policy for oversight of dual use research of concern and pathogens with enhanced pandemic potential. https://www.whitehouse.gov/wp-content/uploads/2024/05/USG-Policy-for-Oversight-of-DURC-and-PEPP.pdf (Executive Office of the President, 2024).
Acknowledgements
This work was supported by the MITRE Corporation. We are grateful to Elizabeth Gehman (the MITRE Corporation) for her constructive comments and recommendations during the preparation of this manuscript.
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Conceptualization: M.C.W., K.J.R., J. Dileo. Methodology: M.C.W., K.J.R., J. Dileo. Investigation: M.C.W., K.J.R., M.J.S., S.R.C., R.L.M., A.A.-J., J. Diggans., J. Dileo. Project administration: M.C.W. Supervision: J. Dileo. Writing – original draft: M.C.W. Writing – review & editing: K.J.R, M.J.S., S.R.C., R.L.M., A.A.-J., J. Diggans, J. Dileo.
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Watson, M.C., Rambhia, K.J., Seltzer, M.J. et al. Toward a safer and more secure US bioeconomy. Nat Biotechnol 43, 23–25 (2025). https://doi.org/10.1038/s41587-024-02519-2
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DOI: https://doi.org/10.1038/s41587-024-02519-2