DNA delivery using lipid nanoparticles results in severe toxicity in mice. However, we find that the incorporation of endogenous anti-inflammatory lipids into the lipid nanoparticles mitigates this toxicity and enables prolonged gene expression.
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This is a summary of: Patel, M. N. et al. Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids. Nat. Biotechnol. https://doi.org/10.1038/s41587-025-02556-5 (2025).
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Improving the safety of lipid nanoparticle-based DNA delivery for extended gene expression. Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02600-4
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DOI: https://doi.org/10.1038/s41587-025-02600-4
