Extended Data Fig. 7: gRNA concentrations in liver tissues.
From: Improved RNA base editing with guide RNAs mimicking highly edited endogenous ADAR substrates
a, gRNA concentrations in livers for mice treated with MIRROR gRNAs with different doses. The mice underwent a single intravenous tail vein injection, and their livers were collected two days later for gRNA quantification. Values are presented as mean ± s.e.m. n = 4. b, gRNA concentrations in livers for indicated MIRROR gRNAs over time. Mice were injected at a single dose of 3 mg kg−1 and livers were collected at different time points across two weeks. Values are presented as mean ± s.e.m. n = 4.
