Extended Data Fig. 7: Time-dependent biodistribution (BD) studies.
From: Antibody–bottlebrush prodrug conjugates for targeted cancer therapy
a. Ex vivo images of organs from mice (n = 3) at different time points following administration of Cy5.5-HER2 and non-targeted controls Cy5.5-IgG1 and Cy5.5-BP. b. Quantification of time-dependent BD for targeted and non-targeted constructs as quantified by fluorescence imaging. The bottom bar graphs correspond to the tumor fluorescence signals for different treatment groups, showing substantially greater tumor accumulation for HER2-targeting Cy5.5-HER2. Results are presented as mean ± SEM (n = 3 biological replicates). Statistical analysis was done using a 2-tailed t-test. For these statistical tests, NS denotes non-significant; *, P < 0.05; **, P < 0.01.
