Extended Data Fig. 9: Images of mice organs and xenografts examined after ABC treatments in the BT-474 xenograft tumor model.
From: Antibody–bottlebrush prodrug conjugates for targeted cancer therapy
Tissue sections were formalin-fixed paraffin-embedded (FFPE), stained with hematoxylin and eosin (H&E), and evaluated by a board-certified veterinary pathologist. a. No sign of toxicity was observed in the heart, lung, liver, spleen, and kidney, supporting a good safety profile. b. Xenografts with different magnifications. Tumor cells were only visible in the PBS, MMAE-BP, and MMAE-IgG1 groups. Tumor-bearing mice were treated with MMAE-based constructs (5 mg/kg mAb; 1.7 mg/kg MMAE per dose). Mice were dosed once a week for a total of 4 doses as illustrated via green arrows in panel a of Fig. 3. Scale bar = 300 μm. For each representative histology image, tissue sections from 4 mice were analyzed independently, with 3 slices examined per mouse, yielding similar results across all samples.
