Extended Data Fig. 5: Functional enrichment of bacterial and fungal differentially expressed genes across skin sites.

(a) Barplots of normalized enrichment scores (NES) computed from gene set enrichment analyses of bacterial or fungal orthologous groups that are differentially enriched between cheek (n = 22) and volar forearm (n = 18) metatranscriptomes. (b) Same as (a) but computed between toe web (n = 18) and volar forearm (n = 18) metatranscriptomes. Pathways which are statistically enriched from both DESeq2 and Maaslin2 analysis are bolded with asterisks for clarity.