Extended Data Fig. 9: Correlation between measured or predicted indel formation at target sites with SpCas9 and ADPr-TAE-mediated base mutation. | Nature Biotechnology

Extended Data Fig. 9: Correlation between measured or predicted indel formation at target sites with SpCas9 and ADPr-TAE-mediated base mutation.

From: Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes

Extended Data Fig. 9

a, Correlation between ADPr-TAE-mediated base mutation frequency and on-targeting scores predicted for indel formation with traditional Cas9. Each dot represents the mean of base mutation frequencies (n = 3) observed experimentally, plotted against scores predicted through the Rule Set 2 scoring method2, for a specific genomic target. b, Correlation between ADPr-TAE base mutation frequency and indels generated by SpCas9. Each dot represents the mean of base mutation frequencies (n = 3), determined by Illumina sequencing against Indels determined through Illumina and Sanger sequencing methods (n = 3), for a specific genomic target.

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