Fig. 6: Programmable ADP-ribosylation of thymine generates distinct editing outcomes in bacteria and eukaryotes compared to deaminase and glycosylase base editing. | Nature Biotechnology

Fig. 6: Programmable ADP-ribosylation of thymine generates distinct editing outcomes in bacteria and eukaryotes compared to deaminase and glycosylase base editing.

From: Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes

Fig. 6

Editors with deaminases include ABEs60 and CBEs61, while editors with glycosylases include A-to-Y BEs41, glycosylase BEs62, adenine transversion BEs63, glycosylase-based guanine BEs64, glycosylase-based TBEs, glycosylase-based CBEs35, DAF-TBEs, DAF-CBEs33, thymine DNA glycosylase-based editor, cytosine DNA glycosylase-based editor42 and TBEs34. Nucleotides representing edits are colored to help compare the glycosylation and ADP-ribosylation of thymine.

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