We developed a universal control system and multitarget optimization framework that enables dynamic and synchronized expression of multiple genes and facilitates the overproduction of specific secondary metabolites in Streptomyces species.
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References
Hutchings, M. I., Truman, A. W. & Wilkinson, B. Antibiotics: past, present and future. Curr. Opin. Microbiol. 51, 72–80 (2019). A review article that presents the Streptomyces genus as a prolific producer of secondary metabolites.
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Montaño López, J., Duran, L. & Avalos, J. L. Physiological limitations and opportunities in microbial metabolic engineering. Nat. Rev. Microbiol. 20, 35–48 (2022). A review article that describes how dynamic control can be used to decouple product biosynthesis from microbial growth.
Qiu, S. et al. Building a highly efficient Streptomyces super-chassis for secondary metabolite production by reprogramming naturally-evolved multifaceted shifts. Metab. Eng. 81, 210–226 (2023). This paper presents an ethanol-induced amplification system in S. venezuelae, which provided insights for the development of the control system used in this study.
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This is a summary of: Yang, B. et al. Scalable secondary metabolite production in Streptomyces using a plug-and-play system. Nat. Biotechnol. https://doi.org/10.1038/s41587-025-02762-1 (2025).
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Orchestration of secondary metabolite production in Streptomyces species. Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02815-5
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DOI: https://doi.org/10.1038/s41587-025-02815-5
