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Big pharma seduced by transcription factors again. What has changed?

Long considered undruggable, transcription factors have finally become fair game for a clutch of innovative biotechs who are combining biological insights with innovative chemistry to bring into play a vast number of new drug targets.

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Sheridan, C. Big pharma seduced by transcription factors again. What has changed?. Nat Biotechnol 43, 1587–1590 (2025). https://doi.org/10.1038/s41587-025-02862-y

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