Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Epigenetics

Durable epigenetic silencing with a TALE-based editor

Nature Biotechnology (2025)Cite this article

Subjects

Transient expression of a transcription activator-like effector (TALE)-based epigenetic editor demonstrates durable therapeutic silencing in non-human primates.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Development of TALE-based epigenetic regulators (EpiRegs) for in vivo silencing of PCSK9 in mice and monkeys.

References

  1. Mao, S. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-025-02838-y (2025).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Amabile, A. et al. Cell 167, 219–232.e14 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Bao, X. et al. Signal Transduct. Target. Ther. 9, 13 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Nuñez, J. K. et al. Cell 184, 2503–2519.e17 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Tremblay, F. et al. Nat. Med. 31, 1329–1338 (2025).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Boch, J. et al. Science 326, 1509–1512 (2009).

    Article  CAS  PubMed  Google Scholar 

  7. Hou, X., Zaks, T., Langer, R. & Dong, Y. Nat. Rev. Mater. 6, 1078–1094 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Hosseini-Kharat, M., Bremmell, K. E. & Prestidge, C. A. Mol. Ther. Methods Clin. Dev. 33, 101436 (2025).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Ray, K. K. et al. N. Engl. J. Med. 382, 1507–1519 (2020).

    Article  CAS  PubMed  Google Scholar 

  10. Cappelluti, M. A. et al. Nature 627, 416–423 (2024).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Bioengineering, Stanford University, Stanford, CA, USA

    Tassilo L. A. Wachsmann & Lei S. Qi

  2. Sarafan ChEM-H, Stanford University, Stanford, CA, USA

    Lei S. Qi

  3. Chan Zuckerberg Biohub – San Francisco, San Francisco, CA, USA

    Lei S. Qi

Authors
  1. Tassilo L. A. Wachsmann
    View author publications

    Search author on:PubMed Google Scholar

  2. Lei S. Qi
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Lei S. Qi.

Ethics declarations

Competing interests

L.S.Q. is a founder of Epicrispr Biotechnologies and scientific advisor to the Laboratory of Genomic Research.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wachsmann, T.L.A., Qi, L.S. Durable epigenetic silencing with a TALE-based editor. Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02871-x

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41587-025-02871-x

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research