H3K4me1 is enriched at active and primed enhancers. However, whether H3K4me1 controls or simply correlates with enhancer activity and function has remained unclear. Several recent reports, including two in Nature Genetics, provide major mechanistic and functional insights into the role of H3K4me1 at enhancers.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer
Nature Genetics Open Access 03 October 2025
-
Single-cell multi-omics delineates the dynamics of distinct epigenetic codes coordinating mouse gastrulation
BMC Genomics Open Access 08 May 2025
-
Enhancers in T Cell development and malignant lesions
Cell Death Discovery Open Access 17 September 2024
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
ENCODE Project Consortium. Nature 489, 57–74 (2012).
Smith, E. & Shilatifard, A. Nat. Struct. Mol. Biol. 21, 210–219 (2014).
Creyghton, M. P. et al. Proc. Natl. Acad. Sci. USA 107, 21931–21936 (2010).
Heintzman, N. D. et al. Nature 459, 108–112 (2009).
Rada-Iglesias, A. et al. Nature 470, 279–283 (2011).
Dorighi, K. M. et al. Mol. Cell 66, 568–576 (2017).
Local, A. et al. Nat. Genet. https://doi.org/10.1038/s41588-017-0015-6 (2017).
Rickels, R. et al. Nat. Genet. 49, 1647–1653 (2017).
Wysocka, J. et al. Cell 121, 859–872 (2005).
Alver, B. H. et al. Nat. Commun. 8, 14648 (2017).
Herz, H.-M. et al. Genes Dev. 26, 2604–2620 (2012).
Lagha, M., Bothma, J. P. & Levine, M. Trends Genet. 28, 409–416 (2012).
Wang, A. et al. Cell Stem Cell 16, 386–399 (2015).
Stadler, M. B. et al. Nature 480, 490–495 (2011).
Ooi, S. K. T. et al. Nature 448, 714–717 (2007).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Rada-Iglesias, A. Is H3K4me1 at enhancers correlative or causative?. Nat Genet 50, 4–5 (2018). https://doi.org/10.1038/s41588-017-0018-3
Published:
Issue date:
DOI: https://doi.org/10.1038/s41588-017-0018-3
This article is cited by
-
Single-cell multi-omics delineates the dynamics of distinct epigenetic codes coordinating mouse gastrulation
BMC Genomics (2025)
-
Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer
Nature Genetics (2025)
-
Enhancers in T Cell development and malignant lesions
Cell Death Discovery (2024)
-
Chromatin protein complexes involved in gene repression in lamina-associated domains
The EMBO Journal (2024)
-
Polymorphisms of ANPEP Gene Are Associated with Microvascular Complications of Type 2 Diabetes
Bulletin of Experimental Biology and Medicine (2024)
