Supplementary Figure 3: QQ plot for gene-based burden tests for association with type 2 diabetes in trans-ancestry cohorts
From: Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
A QQ plot of the P values from gene-based burden tests performed using loss-of-function variants (MAF < 5%) from the Accelerating Medicines Partnership Type 2 Diabetes Knowledge Portal (http://www.type2diabetesgenetics.org/). The analysis was performed as described in the Methods. The inflation factor lambda is the median test statistics divided by the expected median. No systematic inflation of our test statistics is observed.
