Supplementary Figure 5: Association testing with imputed sequence variants in the region of the ABCG2 gene. | Nature Genetics

Supplementary Figure 5: Association testing with imputed sequence variants in the region of the ABCG2 gene.

From: Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals

Supplementary Figure 5

Sequence variant genotypes were imputed into 5,204 Holstein animals using the 1000 Bull Genomes Run4 multi-breed reference population with Minimac44. Association tests were performed between imputed sequence variant genotypes on chromosome 6 and daughter-derived values for protein percentage. Association testing was carried out with EMMAX5 using the -Z flag to consider predicted allele dosages for the imputed sequence variants. The association testing revealed the causal p.Y581S variant in ABCG256 to be the most significantly associated variant in Holstein cattle. The frequency of the minor allele was 0.013. Data were used from Pausch et al10.

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