Supplementary Figure 7: Comparison of conserved regions assessed with CDTS and GERP.

a, Element family composition in the 1st-percentile regions of CDTS (the bar labeled as “CTDS 1st”), GERP (“GERP 1st”) and the overlap region of CDTS and GERP (“Intersection”). Boxes in the bar correspond to different element families. “Others” refers to ENCODE element families that did not cover a substantial part of the genome individually (such as transcription factor binding sites; Methods). The coloring of the boxes is in the same order as in the legend. b, Absolute length of the 1st-percentile regions of CDTS, GERP and the overlap region of CDTS and GERP. Bins without GERP score, due to insufficient multiple-species alignments in the region, were not considered in the ranking process. This explains the total length difference between the 1st-percentile regions of CDTS and GERP. c, Element family composition in the first ten percentile regions of CDTS (the bar labeled as “CTDS 1–10th”), GERP (“GERP 1–10th”) and the overlap region (“Intersection”). d, Absolute length of the first ten percentile regions of CDTS, GERP and the overlap region of CDTS and GERP. CDS, coding sequence; ncRNA, noncoding RNA; CDTS, context-dependent tolerance score; GERP, Genomic Evolutionary Rate Profiling.