Supplementary Figure 2: Comparison of cHi-C and model data in human fibroblast cells after correcting for genomic proximity effects.

The model derived contact matrix (bottom left) of the EPHA4 locus in human fibroblast cells has a high Pearson correlation with our cHi-C data (top left; r=0.93; n=1 with internal control comparing 4 different experiments, see Methods). The matrices in the right panel are obtained by subtraction of the average interaction at a given genomic distance. Interestingly, the patterns in the data are still captured by the model after the effects of genomic distance are subtracted: the Pearson correlation coefficients remains high (r’=0.69).