Supplementary Figure 1: 3′UTR-shortening trans effect is associated with 3′UTR-shortening, but not with methylation changes. | Nature Genetics

Supplementary Figure 1: 3′UTR-shortening trans effect is associated with 3′UTR-shortening, but not with methylation changes.

From: 3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk

Supplementary Figure 1

(a) Scatter plot showing anti-correlation between ceRNA gene expression change in tumors (Y-axis, tumor / normal) vs. degree of 3′UTR shortening in tumors (X-axis, ΔPDUI normal - tumor) of the associated 3′UTR-shortening genes. Methylation level change (tumor vs. normal) on promoter regions (±1 Kbp from TSS) of (b) 158 3′US ceRNA tumor suppressors and the same number of sample control tumor suppressors and (c) PTEN on the 5 randomly-selected tumor normal pairs in More 3′US and Less 3′US groups (defined in Fig. 3d). Statistical significance is estimated from t-test.

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