Supplementary Figure 8: Power calculation of the TWAS analysis.

The simulation analysis is based on 122,977 cases and 105,974 controls. Gene expression was generated from the empirical distribution of predicted gene expression levels in the BCAC. Statistical power was calculated at P < 5.82 × 10–6 (the significance level used in the main TWAS analyses) according for cis-heritability (h2), which we aim to capture using gene expression prediction models (R2). The figure shows results per 1 s.d. increase (or decrease) in the gene expression based on 1,000 replicates.