Supplementary Fig. 2: Modeling WGD in simulated cancer genomes.

At top is the fraction of the autosomal tumor genome with a MCN greater than or equal to two, as in Fig. 1a. In red is the threshold used to determine genome doubling. In green are 1,000 simulated cancer genomes constructed from randomly sampling 22 autosomes from all samples in the cohort indicated; the majority are weighted to WGD-negative samples. Light and dark blue are the same simulations (as in green) repeated but only from randomly sampling WGD-negative and WGD-positive cases, respectively, indicating the inability to simulate a WGD-positive genome (having greater than or equal to 50% of the genome with MCN of two or greater) from chromosomal aberrations drawn from WGD-negative cases.