Supplementary Fig. 7: Neuronal cell body migration distance and neurite length as displayed by stem cell clone identifier. | Nature Genetics

Supplementary Fig. 7: Neuronal cell body migration distance and neurite length as displayed by stem cell clone identifier.

From: Biallelic loss of human CTNNA2, encoding αN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration

Supplementary Fig. 7

Neurosphere neuronal migration assays from human iPSC-derived neuronal progenitor cells were performed with three different iPSCs or H9 hESC CTNNA2-mutant stem cell lines for each experiment. The distribution of migrating neurons is shown as a box plot: top box, Q3; bottom box, Q1; and median. The whiskers represent the minimum and maximum values observed within each of the datasets. 2,194 cells were quantified. During migration, the length of the leading process from the edge of the neuronal cell body to the tip of the growth cone was measured. The distribution of neurite length is shown, depicted as a box plot: top box, Q3; bottom box, Q1; median. The whiskers represent the minimum and maximum values observed for each dataset. 1,574 cells were quantified.

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