Supplementary Figure 13: Simulation showing saturation of new common missense variants discovered by increasing the size of the human cohorts surveyed.
From: Predicting the clinical impact of human mutation with deep neural networks

In simulations, the genotypes of each sample were sampled according to gnomAD allele frequencies. The fraction of gnomAD common variants discovered is averaged across 100 simulations for each sample size from 10 to 100,000.