Supplementary Figure 4: Survival analysis for samples with high or low IgG3–1 switches.
From: Landscape of B cell immunity and related immune evasion in human cancers
a, IgG3–1 switch level is the number of B cell clusters with both IgG1 and IgG3 divided by the total number of unique CDR3s. The group of top 25% samples with high IgG3–1 switch was compared with the bottom 25% samples in terms of the overall survival (see Supplementary Table 3 for sample sizes). Hazard ratios and statistical significance from Wald test were evaluated using Cox proportional hazard regressions corrected for tumor purity and patient age. FDR correction was performed using the Benjamini–Hochberg procedure for testing on multiple cancer types. b, Kaplan–Meier curves for significant tumor types were shown with raw P values at the bottom.
