Supplementary Figure 9: Lack of significant relationship between extent of transcriptome remodeling (number of DE genes) and genetic distance. | Nature Genetics

Supplementary Figure 9: Lack of significant relationship between extent of transcriptome remodeling (number of DE genes) and genetic distance.

From: Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis

Supplementary Figure 9

(a) Scatterplot comparing the number of differentially expressed genes (DE) and the genetic distance of the 442 singleton strains. For each of the strains, genes were called differentially expressed compared to reference strain MGAS28737. Genetic distance was measured as the number of core chromosomal SNPs compared to strain MGAS28737. Red line represents the line of regression. No significant correlation was observed between genetic distance and extent of transcriptome remodeling (number of DE genes) with R2 value of 0.0046. (b) No improvement in correlation (R2 = 0.0040) was observed when the analysis was conducted using only data for the 188 strains that have wild-type alleles for all known major regulatory genes. Red, SC1A; blue, SC1B; green, SC2A; yellow, SC2B. R2 value was calculated by linear regression analysis.

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