Supplementary Figure 1: Distribution of emm28 isolates by country and state in the United States.

All strains were isolated during a 26-year period, spanning 1991 through 2016. (a) Distribution of strains by country. Vertical black bars indicate the number of isolates per year. The total number of strains isolated in the USA was 952, of which 951 strains were collected as part of the Active Bacterial Core (ABC) surveillance study conducted by the Centers for Disease Control and Prevention32,68,111,112 (see https://www.cdc.gov/abcs/index.html for a complete description of the study). The one additional strain (from Texas) is strain MGAS6180, which is the genome sequence reference strain. Canadian strains are all from Ontario. The Faroe Islands are a self-governing part of Denmark. Regardless of country, all strains were recovered as part of comprehensive, population-based studies. (b) Distribution of emm28 isolates by state in the USA. All strains were isolated during a period of 18 years, spanning 1995 through 2012. Vertical black bars indicate the number of isolates per year. For the U.S. isolates, the states have been coded (A-J) at the request of the Centers for Disease Control.