Supplementary Figure 14: Target validation for systemic lupus erythematosus (SLE).
From: A genetics-led approach defines the drug target landscape of 30 immune-related traits
a, Illustration of protein targets (y-axis) targeted by chemical probes (x-axis). Probes are ordered by the number of targets it has. Multiple targets per probe are colour-coded by probe-to-target affinity measured by IC50. b, Epigenetic probe assays tested using cytokine stimulated PBMCs from SLE patients (n = 5 recruited patients on a random basis without a risk for a self-selection bias). c, Physical interaction of the region harboring SLE-associated SNP rs558702 with EHMT2 in Macrophages M0 (promoter capture Hi-C score = 13.99), M1 (13.28) and M2 (10.58). d, Interaction plot for EHMT2 illustrating the top prioritized neighbors of this gene in SLE.
