Supplementary Figure 2: Network analysis supporting principles used by Pi.

a, Enrichment analysis of immune drug targets (of different phases) in terms of GWAS reported genes (left) and GWAS genes plus their interacting neighbors (right). Inserted below is per-trait enrichment analysis focusing on clinical proof-of-concept immune drug targets. Fisher’s exact test (two-sided) used to calculate odds ratio (OR) with 95% confidence interval (CI; represented by lines). GWAS reported genes are sourced from GWAS Catalog (P < 5 × 10⁻⁸), and interaction neighbors of GWAS genes are sourced from the STRING database, defined as interactions with high confidence score. b, Schematic overview showing an approach for identifying pathway crosstalk and assessing the significance level.