Extended Data Fig. 2: Association of SLC30A8 p.Arg138* and p.Trp325Arg with free fatty acids, hormones, and insulin clearance during test meal.
From: Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
Association of SLC30A8 p.Arg138* and p.Trp35Arg variant with a, serum (S)-C-peptide b, S-proinsulin c, plasma (P)-Glucagon d, Total S-GLP-1 e, S-free fatty acid (FFA) concentrations f, Insulin-C-peptide ratio and g, model-based insulin clearance index during test meal. Left panel: Carriers (red, n=50-54) vs. non-carriers (black, n=37-47) of p.Arg138*. Middle panel: Carriers of p.Arg138* (red, n=50-54) vs. p.Arg138Arg having the common risk variant p.Arg325 (blue, n=25-31). Right panel: Carriers of p.Trp325Trp (grey, n=12-16) vs. p.Arg325 (blue, n=25-31). Exact numbers used for genetic association analysis are available in Source Data files. Data are Mean ±SEM; A star (*p < 0.05, ** p < 0.01) indicates significance in family based association (using QTDT35) after 100,000 permutations, adjusted for age, sex and BMI for left panel and age, sex, BMI and genotype of p.Trp325Arg for middle panel. A hash sign (# p < 0.05) indicates significance in QFAM (as implemented in PLINK36) test using 100,000 permutations (see Methods).
