Extended Data Fig. 4: Tissue-specific genes have more distal enhancers than ubiquitously expressed genes.
From: Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations
a, Left: Comparison of ABC scores (predicted effect) with observed changes in gene expression upon CRISPR perturbations. Each dot represents one tested DE-G pair where G is a ubiquitously expressed gene. Right: precision-recall curve for ABC score in classifying regulatory DE-G pairs where each G is a ubiquitously expressed gene. b, Same as a for tissue-specific genes. All panels include only the subset of our dataset for which we have CRISPRi tiling data to comprehensively identify all enhancers that regulate each gene (30 genes from this study, 2 from previous studies; see Supplementary Methods).
