Extended Data Fig. 6: Overview and examples of metabolite clustering. | Nature Genetics

Extended Data Fig. 6: Overview and examples of metabolite clustering.

From: Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans

Extended Data Fig. 6

(a) shows the dendrogram of the metabolite clustering. The band of color indicates membership of each of the 1,172 metabolites in one of 212 clustered metabolite modules. (b) illustrates module ME193, for which metabolites are labeled. (c) displays the distribution of the eigenmetabolite of ME193 (y axis) with genotype at rs2147896 in PYROXD2 (x axis). (d) illustrates module ME161, for which metabolites are labeled. (e) displays the distribution of the eigenmetabolite of ME161 (y axis) with genotype at rs13538 in NAT8 (x axis). In (c) and (e) horizontal lines indicate medians, violin plots are clipped to the range of the 1,627 samples.

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