Fig. 1: Identification of the new MIRb-ACE2 isoform. | Nature Genetics

Fig. 1: Identification of the new MIRb-ACE2 isoform.

From: Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option

Fig. 1

a, GENCODE annotated transcripts at the ACE2 locus, intronic position of the MIRb and LTR16A1 elements, structure of the new MIRb-ACE2 isoform and RNA-seq traces of composite LUAD and LUSC samples. Also shown is splice junction analysis of the same RNA-seq samples. b, Phylogenetic analysis of the MIRb and LTR16A1 sequences in the indicated representative mammalian species and percentage sequence identity to the consensus MIRb and LTR16A1 sequences. The arrows indicate the estimated timing of ancestral integrations of the MIRb and LTR16A1 elements, respectively. Ma, million years ago; NA, not applicable. c, Alignment of the MIRb and LTR16A1 sequences in the indicated representative mammalian species and of the consensus MIRb and LTR16A1 sequences.

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