Extended Data Fig. 2: 5’ RACE PCR support for transcriptional initiation of the MIRb-ACE2 transcript. | Nature Genetics

Extended Data Fig. 2: 5’ RACE PCR support for transcriptional initiation of the MIRb-ACE2 transcript.

From: Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option

Extended Data Fig. 2

Middle panel: Putative transcription factor binding sites, predicted by PROMO (http://alggen.lsi.upc.es/cgi-bin/promo_v3/promo/promoinit.cgi?dirDB=TF_8.3), in the intronic MIRb and LTR16A1 elements in the ACE2 locus. A putative TATA-box is also depicted. Lower panel: Mapping of sequencing reads of 5’ RACE PCR products from IFNα-stimulated primary NHBE cells or SCC-4 and SCC-25 cell lines in the intronic MIRb and LTR16A1 elements in the ACE2 locus. A detailed view of CAGE data (from Extended Data Fig. 1) spanning the same region is also included for comparison.

Back to article page