Extended Data Fig. 3: TSCs are a small subset of overall enhancers as defined by SMAD1 and GATA co-occupancy. | Nature Genetics

Extended Data Fig. 3: TSCs are a small subset of overall enhancers as defined by SMAD1 and GATA co-occupancy.

From: Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits

Extended Data Fig. 3

a, Venn diagram representing genomic regions co-occupied by different STFs - SMAD1, SMAD2 and TCF7L2 in progenitor CD34+ cells upon stimulation with BMP4, TGFβ and WNT signaling, respectively. The genomic regions bound by all three factors are 4549. The other numbers refer to the total number of peaks bound by each factor combination, as indicated. Regions are considered occupied if they pass a significant coverage cutoff. b, Table representing different strategies to define enhancers using H3K27ac ChIP-seq and/or ATAC-seq. The proportion of enhancers that can be classified as TSCs (GATA+SMAD1 co-bound) at progenitor (D0) or erythroid (D5) stages are as indicated.

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