Extended Data Fig. 4: The interaction of between-ancestry MAF differences and effect sizes on Tractor power. | Nature Genetics

Extended Data Fig. 4: The interaction of between-ancestry MAF differences and effect sizes on Tractor power.

From: Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power

Extended Data Fig. 4

In all cases, the grey solid line uses a traditional GWAS model while the black dashed line is our LAI-incorporating model, admixture proportions are 80/20 AFR/EUR, disease prevalence is 10%, and the AFR MAF is fixed at 20%. A and E model the same effect size between EUR and AFR while varying the EUR MAF. B,D,F model the case when there is no effect in the EUR background while varying EUR MAF. C models an effect size difference of 30% with the effect being stronger in the EUR background. For comparison, Fig. 2f shows the same effect at matched 20% MAF.

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