Extended Data Fig. 2: Polygenic risk scores in MVP and PGC-PTSD. | Nature Genetics

Extended Data Fig. 2: Polygenic risk scores in MVP and PGC-PTSD.

From: Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program

Extended Data Fig. 2

Polygenic risk score (PRS) from MVP EUR case-control (left) and EUR PCL-total (right) applied to PGC-PTSD13 case-control phenotype with varying P-value thresholds (PT) on the x-axis and explained variance (R2) on the y-axis. The approximate estimate of the explained variance was calculated using a multivariate regression model. P values reported are two sided, and Bonferroni correction accounting for the number of P-value thresholds tested is P = 2.38 × 10−4.

Back to article page