Extended Data Fig. 5: MYC is a drug-induced AP gene.
a, Correlogram depicting Pearson correlation coefficients of MYC, NSD3, NSD2, EED and EZH2 depletion values across nine drug modifier screens. Data from drug-modifier screens conducted in n = 2 biologically independent experiments. b,c, Confirmation of MYC shRNA knockdown in OCI-AML2 by transcript (b) and protein (c). Representative immunoblot of n = 3 independent experiments. d,e, JQ-1 (d) and ABT-199 (e) 8-point drug dilution series following shRNA knockdown of MYC in OCI-AML2 cells. f,g, Confirmation of MYC overexpression in OCI-AML2 by transcript (f) and protein (g). Representative immunoblot of n = 3 independent experiments. h,i, JQ-1 (h) and ABT-199 (i) 8-point drug dilution series following overexpression of MYC in OCI-AML2 cells. b,f; P-values computed by two-sided two-sample t-Test for equal means. b,d–f,h,i, Data are mean ± SEM for n = 3 biologically independent experiments. Uncropped blots in Source Data.
