Extended Data Fig. 6: EZH2/EED/NSD2/NSD3 modulate JQ-1 and ABT-199 sensitivity through MYC.
a,b; d,e, Relative expression of NSD2 (a), NSD3 (b), EZH2 (d), and EED (e) transcripts in cells with CRISPR/Cas9 knockout. P-values computed by two-sided two-sample t-Test for equal means. Data are presented as mean ± SEM for n = 3 biologically independent experiments. c,f, 8-point dose-response curves of JQ-1 (c) and ABT-199 (f) following CRISPR/Cas9 knockout of NSD2/3 (c) and EZH2 or EED (f). Data are presented as mean ± SEM for n = 3 biologically independent experiments.
