Extended Data Fig. 4: Expression of genes located in the associated loci (from Supplementary Table 3) along the x-axis, across several human body tissues (y-axis).

The colors represent the centile ranking of the expression level of the gene in the tissue of interest. The hotter colors represent higher ranking of the gene expression and the colder colors low expression. Both genes and tissues are clustered in accordance with their pattern similarity. The symbol of all the genes could not be visualized and therefore are removed for the sake of clarity. Eye tissues, whether fetal or adult, appear to have similar patterns of gene expressions (clustered together at the bottom of the figure). Genes that are highly expressed in eye tissues fall in three clusters, shown with a black box. These clusters are displayed in more detail in Figure 4A, B and C.