Extended Data Fig. 7: Mendelian randomization results on causality of IOP over refractive error. Single points in the graph represent coordinates determined by the effect of each specific SNP over IOP (x-axis, mmHg) and spherical equivalent (y-axis, Diopter units). | Nature Genetics

Extended Data Fig. 7: Mendelian randomization results on causality of IOP over refractive error. Single points in the graph represent coordinates determined by the effect of each specific SNP over IOP (x-axis, mmHg) and spherical equivalent (y-axis, Diopter units).

From: Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

Extended Data Fig. 7

A total of 73 SNPs associated with IOP, but not directly associated with refractive error (that is p > 0.05) were selected as instruments. Values of associations with IOP were obtained from a meta-analysis of 139,555 European participants (Reference 50 in the manuscript) and the refractive error associations from 102,117 UK Biobank subjects. The lines represent the regression lines from each model, as specified in the figure legend. In some cases, these lines may not visible because they overlap (please refer to the values underneath the figure).

Back to article page