Extended Data Fig. 1: Harvesting and harmonizing records. | Nature Genetics

Extended Data Fig. 1: Harvesting and harmonizing records.

From: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer

Extended Data Fig. 1

Harvested interpretation records (left column) from each knowledgebase vary in structure, a consequence of how they are represented and exported by their parent knowledgebase. Knowledgebase-specific rules are written to select data from harvested records for harmonization across a suite of element-specific harmonizers (center column). Colors represent different elements of an interpretation, which are each harmonized independently: genes (green), variants (cyan), diseases (red), drugs (purple), and evidence (yellow). Outputs from these harmonizers are assembled into normalized records (right column).

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