Extended Data Fig. 6: DNMT1 has imprecise methylation replication activity. | Nature Genetics

Extended Data Fig. 6: DNMT1 has imprecise methylation replication activity.

From: Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance

Extended Data Fig. 6

a, Methylation fidelity is as defined by the percentages of symmetrically methylated or un-methylated CG dyads among all sequenced reads at a given CG position. 100% fidelity indicates all CG dyads are symmetrically methylated or un-methylated, while 0% fidelity indicates all CG dyads are asymmetrically methylated. b, Bar charts showing DNA methylation fidelity of WT, PKO, and SKO mESCs when treated with or without nocodazole. c, Bar charts showing the CG coverages with different sequence depths for SKO clonal samples. d, Bar charts showing DMR number (left) and genome coverage (right) under different methylation cutoffs comparing D60 to D15 samples. e, Heatmaps showing the various DNA elements and repeats enrichment at D60 vs. D15 DMRs. The enrichment was calculated as a log2 ratio for the numbers of DMRs that overlap with repeats divided by the numbers of a random set of CGs that overlap with repeats. f, Bar charts showing the enriched gene ontology (GO) terms for genes associated with D60 vs. D15 DMRs. P-values (Fisher’s exact test, two-sided, not adjusted by multiple comparisons) are transformed by log10. g, UCSC genome browser snapshots showing D60 vs. D15 DMRs.

Back to article page