Extended Data Fig. 7: Convergence of methylome during clonal expansion through “neighbor-guided correction”. | Nature Genetics

Extended Data Fig. 7: Convergence of methylome during clonal expansion through “neighbor-guided correction”.

From: Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance

Extended Data Fig. 7

a, Boxplots showing DNA methylation levels, CG densities and neighbor mCG densities (100-bp bin) for retained, intermediate and reverted expansion-DMCs in C2 (n = 1) and C3 (n = 1) samples. The median is indicated by the center line. The bottom, top edges and whiskers represent the 25th and 75th percentiles and 1.5 times the IQR, respectively. One-sided P values (Mann-Whitney U test) are also shown. b, Boxplots showing DNA methylation levels, CG and neighbor mCG densities (100-bp bin) of retained, intermediate and reverted interclone-DMCs for D15 samples (C2 vs. C1) (n = 1). The median is indicated by the center line. The bottom, top edges and whiskers represent the 25th and 75th percentiles and 1.5 times the IQR, respectively. One-sided P values (Mann-Whitney U test) are also shown.

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