Extended Data Fig. 8: Analyses of maintenance and de novo methylation activities of DNMT1. | Nature Genetics

Extended Data Fig. 8: Analyses of maintenance and de novo methylation activities of DNMT1.

From: Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance

Extended Data Fig. 8

a, Schematic showing the dynamics of DNA methylation states after each cell division. For each CG, (0,0), (1,0), (0,1), and (1,1) refer to un-methylated, two types of hemi-methylated, and fully-methylated states. Red arrows refer to the conversion of four methylation states during DNA replication. Blue arrows refer to the conversion of four methylation states by maintenance probability (M) and de novo methylation probability (D). When reaching methylation equilibrium, the same methylation states would be re-generated after each cell cycle with a proper M-D pair (Methods). b, Line graphs showing the average maintenance probability (M) and de novo probability (D) in the whole genome, or in regions with or without H3K9me2 (ref. 56), according to different neighbor mCG densities.

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