Extended Data Fig. 5: Features of eSTARR-seq enhancers.
From: Transcription imparts architecture, function and logic to enhancer units
a, Scatterplot of activity vs GRO-cap reads from eSTARR enhancers in K562 cells. b, Metaplots of average H3K27ac, H3K4me3, and H3K4me1 ChIP-seq signal from different element classes defined in K562 cells. Promoters are defined as GRO-cap divergent TSSs within 500 bp of GENCODE gene start, whereas enhancers are defined as GRO-cap divergent TSSs with significant eSTARR activity. Below, ChIP-seq to GRO-cap signal ratio is shown within the window. c, Metaplots of average H3K27ac, H3K4me3, and H3K4me1 ChIP-seq signal from different element classes defined in GM12878 cells. Promoters are defined as GRO-cap divergent TSSs within 500 bp of GENCODE gene start, whereas enhancers are defined as GRO-cap divergent TSSs with significant HiDRA activity. Below, ChIP-seq to GRO-cap signal ratio is shown within the window. n = 860 promoter DHS, 119 transcribed enhancer DHS, 1,100 untranscribed DHS.
