Extended Data Fig. 6: Functional dissection of genomic TSS clusters.
From: Transcription imparts architecture, function and logic to enhancer units
a, Comparison of forward vs reverse cloning orientation for all tested TSS clusters. Data points are shown as log2 fold-change vs negative controls (magenta), averaged from three replicates. Positive controls (black) are known MYC or viral enhancers. Clusters with significantly elevated activity in both orientations are called enhancers (green). All other clusters are called inactive (gray). b, Comparison of sub-element activities within active enhancer clusters. The stronger sub-element is always chosen to be e1, and the weaker sub-element is e2. Gray lines indicate approximate significance cut-offs.
