Extended Data Fig. 4: VAF distribution of neoantigens under different selection strengths and mutation-antigenicity thresholds.
From: Evolutionary dynamics of neoantigens in growing tumors
Cumulative VAF distribution as a function of the inverse of the frequency, for all mutations (grey) and antigenic mutations (red) at increasing selection strengths (top to bottom) and mutation-antigenicity threshold (Tm) applied to label mutations as antigenic (left to right). The thick line shows the mean of 100 simulated cumulative distributions, the shaded regions represent ±1 standard deviation around this mean.
