Extended Data Fig. 1: The comparative landscape of spontaneous and chemically induced tumours with genomic features.
From: The mutational signature profile of known and suspected human carcinogens in mice
a, Comparison of the colocalization of substitutions with histone marks and open chromatin in spontaneous and chemically induced tumours. Each point is a single replicate (for the induced these points are aggregated across multiple chemicals). For each point, we plot the observed/expected data from the MutationalPatterns software. The box plots show the Tukey statistics: The box shows the 1st—3rd quartiles, with a line at the median. The whiskers extend from the 1st and 3rd quartiles to the largest value no more than 1.5*IQR from the relevant quartile (See Source Data for sample numbers in each comparison). b, Table reporting the adjusted P values for the comparisons in a. A two-sided Mann-Whitney U-test was used to calculate the false-discovery rate corrected P values. c, Signatures identified using sigProfiler in the pentanucleotide context.
