Extended Data Fig. 4: The landscape of Mouse Doublet Base Substitution (mDBS) Signatures induced by chemical exposures and endogenous mutagenic processes.
From: The mutational signature profile of known and suspected human carcinogens in mice
a, The catalogue of mouse doublet base substitution (mDBS) signatures. mDBS_N1 and mDBS_N2 are new DBS signatures. b, Number of mutations for each mDBS signature across the collection of lung, liver, kidney and forestomach tumours. Component 0 accounts for very few mutations and represents background mutations. c, The DBS spectrum obtained by normalizing and averaging the DBS spectra of the six lung tumours exposed to cobalt. This profile is almost identical to mDBS_N2.
