Extended Data Fig. 8: eQTL and colocalisation in relation to GTEx.
From: Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation
a, Fraction of GTEx brain eGenes that could be assessed in each of the considered contexts (cell type-conditions; Methods). b, Fraction of GTEx brain eQTL that were replicated in this study (nominal p < 0.5; fraction relative to the set of assessed genes from a). c, Figure analogous to main text Fig. 4c, additionally including eQTL counts from a pseudobulk eQTL analysis (top red dot on the left, red square on the right; calculated using cells from all day 52 cells untreated pooled). d, Figure analogous to main text Fig. 5a, additionally including colocalisation results from a pseudobulk eQTL analysis (using cells from all day 52 cells untreated pooled). In the box plots, the middle line is the median and the lower and upper edges of the box denote the first and third quartiles, while the violin plots show the distribution. Legend: Astro: Astrocytes-like; DA: Dopaminergic neurons, Epen1: Ependymal-like1, FPP: Floor Plate Progenitors, P_FPP: Proliferating Floor Plate Progenitors, Sert: Serotonergic-like neurons.
