Extended Data Fig. 5: Chromatin signatures of 23 ultraconserved enhancers mutated in this study in multiple tissues and developmental times points in mouse and human.

a, Histone modifications associated with active enhancers (H3K27ac) and inactive sequences (H3K27me3) sampled from multiple tissues throughout mouse development. ‘+‘ and ‘-‘ for ‘Tg⁺ e11.5’ indicate the presence or absence, respectively, of the activity by the reference enhancer allele in e11.5 (e12.5 for hs124) transgenic mouse embryos reported in this study. ChIP-seq data was obtained from Gorkin et al., 2020⁴⁰. b, Binding of Dlx transcription factors during embryonic development of mouse basal ganglia. ChIP-seq data was obtained from Lindtner et al., 2019⁴¹. c, Binding of CTCF in embryonic and adult mouse tissues and adult human tissues. ChIP-seq data was obtained from Yue et al., 2014⁴² for mouse samples and from Dunham et al., 2012⁴³ for human samples.